TFMPP hydrochloride → 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]-1-trans-propene hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	TFMPP hydrochloride	HCID 3084246	—
Reactant	1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-propanone hydrochloride	HCID 22097301	—
Reactant	1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)-1-trans-propene hydrochloride	HCID 22097305	—
Product	1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]-1-trans-propene hydrochloride	HCID 22097282	—

Reaction Steps

The procedures of Example 6 (1) and (2) were repeated but substituting the 1,2,3,4-tetrahydroisoquinoline hydrochloride employed in Example 6 (1) by 730 mg of 1-(3-trifluoromethylphenyl)piperazine hydrochloride. After the completion of the post treatment, 75 mg of the title compound was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05852019
Source dataset	uspto-grants-1998_12
ORD ID	ord-50bb966d161d489a956ce29cece50e58
Source note	uspto-grants-1998_12