Formaldehyde → 1-[5-Methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(2-pyrimidinyl)-1-piperazinyl]-1-propanone dihydrochloride

Participants

Reaction Steps

404 mg of 4-acetyl-1-(2-pyrimidinyl)-5-methylpyrazole and 474 mg of 1-(2-pyrimidinyl)piperazine dihydrochloride were dissolved in 15 ml of ethanol and heated under reflux for 23 hours. During this period, 900 mg of paraformaldehyde was added thereto in portions. The reaction mixture was cooled, and the precipitate thus formed was taken up by filtration and washed with methanol. Thus 327 mg of the title compound was obtained in the form of a colorless solid product.

Provenance & Evidence