1-(3-Nitrophenyl)piperazine → 1-(2-Pyrimidinyl)-4-acetyl-5-methylpyrazole
Reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH2:15]CNCC2)[CH:7]=CC=1)([O-])=O.Cl.[CH2:17]([OH:19])[CH3:18]>>[C:17]([C:5]1[CH:4]=[N:1][N:10]([C:15]2[N:10]=[CH:6][CH:5]=[CH:4][N:1]=2)[C:6]=1[CH3:7])(=[O:19])[CH3:18]Participants
3
Procedure
487 mg of 4-acetyl-1-(2-pyrimidinyl)-5-methylpyrazole, 524 mg of the compound obtained in the above (1) and 3.6 ml of a 1N hydrochloric acid/ethanol solution were dissolved in 40 ml of ethanol and heated under reflux for 54 hours. During this period, 4.3 g of paraformaldehyde was added thereto in portions. After cooling, the insoluble matters were collected by filtration. Thus 630 mg of the title compound was obtained in the form of a yellow solid product.
Sources & evidence
- ORD record
- ord-b8651bd58176401f85e35c06784febab
- Source dataset
- uspto-grants-1998_12
- Patent number
- US05852019
Reaction notes
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