HRID1459028

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

HCID6098997

N-(6-Chloro-3H-purin-2-yl)ethanimidic acid

C7H6ClN5O

结构：CC(=O)OC[C@H]1O[C@@H](c2ncc3[nH]cnc3n2)[C@H](OC(C)=O)[C@@H]1OC(C)=O

HCID69884339

未命名化合物

PRODUCTS

生成物

结构：Nc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@H](O)[C@H]3O)c2n1

HCID14284102

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID24182

未命名化合物

PROCEDURE

实验过程

The chloromercury derivative of 2-acetamido-6-chloropurine is condensed with 2,3,5-tri-O-acetyl-β-D-ribofuranosylpurine utilizing the method of Lee et. al. (1971), J. Med. Chem., 14:819. The condensation product was treated with ammonia to yield 2-amino-6-chloro-9-(β-D-xylofuranosyl)purine. Further treatment with sodium hydroxyethylmercaptide gives the title compound.