反应详情

温度

40 °C

(±)-2-(3-Benzoylphenyl)propionic acid (20.3 g, 80 mmol) was dissolved in methyl isobutyl ketone (hereinafter abbreviated to "MIBK") (90 g) with heating. Then, (S)-(+)-3-methyl-2-phenylbutylamine (6.68 g, 41 mmol) was added dropwise with stirring at 40° C. After completing the addition, the reaction solution was stirred at 40° C. for one hour and then cooled slowly to 10° C. over 6 hours. After stirring at 10° C. for 3 hours, the precipitated crystal was filtered and the filter cake was washed with cold MIBK (50 ml) and then dried. In this manner, a diastereomer salt (11.5 g) of (S)-(+)-2-(3-benzoylphenyl)propionic acid with (S)-(+)-3-methyl-2-phenylbutylamine was obtained.

1. temperaturewith heating
2. additionthe addition
3. stirringthe reaction solution was stirred at 40° C. for one hour
4. temperaturecooled slowly to 10° C. over 6 hours
5. stirringAfter stirring at 10° C. for 3 hours
6. filtrationthe precipitated crystal was filtered
7. washthe filter cake was washed with cold MIBK (50 ml)
8. customdried