1-(1-Benzyloxycarbonyl-4-piperidinyl)-3-[4-(2-methoxycarbonyl-ethyl)-phenyl]-imidazolidin-2-one → 1-[4-(2-Methoxycarbonyl-ethyl)-phenyl]-3-(4-piperidinyl)-imidazolidin-2-one

HRID 1459069Notes

Reaction equation

HRID 1459069 reaction equation
C(OC([N:11]1[CH2:16][CH2:15][CH:14]([N:17]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[CH:26][C:25]([CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])=[CH:24][CH:23]=3)[C:18]2=[O:34])[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:33][O:32][C:30]([CH2:29][CH2:28][C:25]1[CH:26]=[CH:27][C:22]([N:19]2[CH2:20][CH2:21][N:17]([CH:14]3[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]3)[C:18]2=[O:34])=[CH:23][CH:24]=1)=[O:31]

Participants

5

Reactant 2

HCID 220987731-(1-Benzyloxycarbonyl-4-piperidinyl)-3-[4-(2-methoxycarbonyl-ethyl)-phenyl]-imidazolidin-2-oneHCID 178418361HCID 178418361, compound

Product 1

HCID 220984701-[4-(2-Methoxycarbonyl-ethyl)-phenyl]-3-(4-piperidinyl)-imidazolidin-2-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Prepared by treating 1-(1-benzyloxycarbonyl-4-piperidinyl)-3-[4-(2-methoxycarbonyl-ethyl)-phenyl]-imidazolidin-2-one with hydrogen at 3 bars in the presence of 5% palladium/charcoal in methanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c15af76b6db7434cbc49e222c98f721f
Source dataset
uspto-grants-1998_12
Patent number
US05852192

Reaction notes

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