HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → Boronic acid, [3-fluoro-4-(octyloxy)phenyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Trimethyl borate | HCID 8470 | — |
| Reactant | (2,3-Difluorophenyl)boronic acid | HCID 2734333 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | Boronic acid, [3-fluoro-4-(octyloxy)phenyl]- | HCID 10611926 | — |
Reaction Steps
Quantities: compound 11 (10.00 g, 0.033 mol) in anhydrous THF (132 ml), n-butyllithium (16 ml, 2.5M in hexane, 0.04 mol), trimethyl borate (6.87 g, 0.066 mol) in anhydrous THF (50 ml). The experimental procedure was as described for the preparation of compound 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05853613 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-8c54cafe745b4408b9532a39c9137552 |
| Source note | uspto-grants-1998_12 |