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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1459110Generated: October 26, 2026

tert-Butyl bromoacetate → N-Benzyloxycarbonyl-3-[4-(tert-butoxycarbonylmethoxy)-phenyl]-alanine-tert-butyl ester

https://huagongshe.com/reaction/1459110

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl bromoacetateHCID 79177—
ReactantZ-Tyr-OtBuHCID 11428694—
ProductN-Benzyloxycarbonyl-3-[4-(tert-butoxycarbonylmethoxy)-phenyl]-alanine-tert-butyl esterHCID 22940773—

Reaction Steps

5.57 g (15 mmol) of N-benzyloxycarbonyl-tyrosine-tert-butyl ester is reacted with bromoacetic acid-tert-butyl ester to alkylated phenol analogously to Example 3a).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05853699
Source datasetuspto-grants-1998_12
ORD IDord-2af71e2039a648d1b44c0c32e17d84f1
Source noteuspto-grants-1998_12