HCID 15278738, compound → HCID 15278739, compound

HRID 1459286Notes

Reaction equation

HRID 1459286 reaction equation
[C:1]([NH:5][S:6]([C:9]1[CH:14]=[C:13]([N+:15]([O-])=O)[CH:12]=[CH:11][C:10]=1[S:18]([CH2:21][CH3:22])(=[O:20])=[O:19])(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:15][C:13]1[CH:12]=[CH:11][C:10]([S:18]([CH2:21][CH3:22])(=[O:20])=[O:19])=[C:9]([S:6]([NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])(=[O:7])=[O:8])[CH:14]=1

Participants

5

Reactant 2

HCID 15278738HCID 15278738, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15278739HCID 15278739, compoundYield 89.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 40 g of N-tert-butyl-2-ethylsulfonyl-5-nitrobenzenesulfonamide is dissolved in 1500 ml of methanol, 0.5 g of 10% palladium on charcoal is added and the mixture is stirred under a hydrogen atmosphere (1 atmosphere). When the uptake of hydrogen has ended, the catalyst is separated off and the solution is concentrated. 32.9 g of the aniline derivative are thus obtained;

Workup

  1. customthe catalyst is separated off
  2. concentrationthe solution is concentrated

Sources & evidence

ORD record
ord-5a0e8fa9e4644785a5d1c0d69a262247
Source dataset
uspto-grants-1998_12
Patent number
US05854179

Reaction notes

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