反应详情

To 4-[2-(biphenyl-4-yloxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester (100 mg, 0.259 mmol) in ethanol (6 mL) was added a solution of sodium hydroxide (1N, 0.41 mL, 0.41 mmol) and the reaction was stirred at room temperature for 30 hours. After such time the reaction mixture was filtered through glass wool and the filtrate was then neutralized by addition of a solution of hydrochloric acid (1N, 0.39 mL). The precipitate was filtered, washed with water and dried in vacuo to yield the title compound as a white solid (96 mg, 80%).

1. filtrationAfter such time the reaction mixture was filtered through glass wool
2. additionthe filtrate was then neutralized by addition of a solution of hydrochloric acid (1N, 0.39 mL)
3. filtrationThe precipitate was filtered
4. washwashed with water
5. customdried in vacuo