Methyl iodide → HCID 69848741, compound

Participants

Reaction Steps

Under a N2 atmosphere in 50 ml of acetone were combined 0.432 g (1 mmol) of bispyridylmethyl N-1-adamantyl thiohydantoin, 0.138 g (1 mmol) of potassium carbonate and 0.142 g (1 mmol) of methyl iodide and the reaction mixture was allowed to stir at room temperature for 48 hours. The reaction mixture was concentrated in vacuo and partitioned in 100 ml EtOAc/10 ml H2O. The organic layer was separated, washed with H2 O(4×10 ml), brine (1x), dried over NaSO4 and concentrated in vacuo. The crude product was purified via column chromatography (silica gel: 92.5/7.25 EtOAc/MeOH) and crystallized from isopropyl ether/hexane (IPE/Hex) to yield N-1-adamantylimidazolinone

Provenance & Evidence