Triphenylphosphine → HCID 69850004, compound

Participants

Reaction Steps

Under N2 atmosphere were combined N-adamantan-1-yl-4-hydroxy-2,2-bis-pyridin4-ylmethyl-butyramide (50 mg, 0.24 mmol), triphenylphosphine (63 mg, 0.24 mmol), and diisopropylazodicarboxylate (0.047 ml, 0.24 mmol) in 5 ml THF and the resulting solution was allowed to stir for 18 hours. The reaction mixture was then placed directly on a silica gel column and eluted with 85:15 mix of EtOAc/MeOH to yield 46 mg of product as a gum which in turn could be crystallized from isopropylether/hexane to yield the desired product as a white solid, m.p. 163.5°-165° C.

Provenance & Evidence