Lithium Hydroxide → HCID 86753476, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 11-11 (0.79 g, 2.38 mmol) in 1:1 THF/MeOH (30 mL) was treated with LiOH (0.95 g, 23.8 mmol) in 10 mL of H2O and heated to 30° C. overnight. The solvents were removed under vacuum and the residue was dissolved in H2O and acidified with 10% KHSO4 and extracted with EtOAc. The organic layer was dried over MgSO4, filtered and evaporated to give 11-12 as an off-white solid.

Provenance & Evidence