反应详情

To a Parr flask was added methyl 5-nitrothiophene-2-carboxylate (5.00 g, 26.71 mmol) and MeOH (100 mL). The solution was purged with a stream of Ar, and 5% platinum on sulfide carbon (2.00 g) was added. The mixture was hydrogenated on a Parr apparatus set at 50 psi for 6.5 hours. The reaction was then filtered through celite and the solvents removed in vacuo to yield methyl 5-aminothiophene-2-carboxylate as an olive green oil.

1. customThe solution was purged with a stream of Ar, and 5% platinum on sulfide carbon (2.00 g)
2. additionwas added
3. filtrationThe reaction was then filtered through celite
4. customthe solvents removed in vacuo