反应详情

温度

130 °C

A mixture of 2-chloronicotinic acid (10.0 g) and benzylamine (13.34 ml) was heated at 130° C. for 2 hours. The mixture was cooled and the resulting solid was broken up, triturated with water, acidified to pH 6 and filtered. The solid obtained was boiled up in IMS (200 ml), cooled and filtered to give 2-benzylaminonicotinic acid, m.p. 223°-225° C.

1. temperatureThe mixture was cooled
2. customtriturated with water
3. filtrationfiltered
4. customThe solid obtained
5. temperaturecooled
6. filtrationfiltered