4-Chlorobenzylamine → Nicotinic acid, 2-(p-chlorobenzylamino)-

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloronicotinic acid (30.0 g) and 4-chlorobenzylamine (45 ml) was heated at 120° C. for 3.5 hours. The mixture was cooled to ambient temperature and the solid obtained was washed with water and collected by filtration. The solid was boiled in methanol and filtered to give 2-(4-chlorobenzylamino)-nicotinic acid, m.p. 240°-242° C.

Provenance & Evidence