4-Amino-5-chloro-2,3-dihydro-7-benzofurancarboxamide → HCID 53931156, compound

Participants

Reaction Conditions

Reaction Steps

Intermediate 7 (0.12 mol) was added to phosporous oxychloride (120 ml) and the reaction mixture was stirred for 45 minutes at 100° C. The mixture was cooled and the solvent evaporated. The residue was added to ice and the mixture was extracted with CH2Cl2 and methanol. The organic layer was dried over MgSO4, filtered and the solvent evaporated. The residue was purified by column chromatography on silica gel (eluent: CH2Cl2 /CH3OH 99/1). The pure fractions were collected and the solvent evaporated, yielding 14.5 g (63%) of 4-amino-5-chloro-2,3-dihydro-7-benzofuran-carbonitrile (intermediate 8).

Provenance & Evidence