2-Chloro-5-nitrobenzaldehyde → Benzaldehyde, 2-methoxy-5-nitro-

Participants

Reaction Steps

A mixture of 2.5 grams (13.5 mmol) of 2-chloro-5-nitrobenzaldehyde (Aldrich Chem. Co.) in 250 mL of CH3OH was treated with 2.92 grams (54.1 mmol) of sodium methoxide, refluxed for 16 hours and allowed to cool to room temperature. After removal of the solvent in vacuo, the residue was suspended in water, treated with 2N HCl (adjusting to pH <5) and extracted into methylene chloride. After drying over MgSO4 , the solvent was removed in vacuo to give a yellow solid, 2.02 grams (83%).

Provenance & Evidence