HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroethanol → (2R,3R,4R)-3,4-Dibenzyloxy-2-benzyloxymethyl-1-(2-hydroxyethyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroethanol | HCID 34 | — |
| Reactant | (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethylpyrrolidine | HCID 22842874 | — |
| Reactant | (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxy-methyl-1-cyclopropylmethylpyrrolidine, hydrochloride | HCID 131721050 | — |
| Product | (2R,3R,4R)-3,4-Dibenzyloxy-2-benzyloxymethyl-1-(2-hydroxyethyl)pyrrolidine | HCID 54162120 | — |
Reaction Steps
The title compound was prepared as described for compound 8 using (2R,3R,4R)-3,4-dibenzyloxy-2-benzyloxymethylpyrrolidine (Compound 1) (0.51g, 1.27 mmol) and 2-chloroethanol (0.1ml, 1.49 mmol) as starting material. (2R,3R,4R)-3,4-Dibenzyloxy-2-benzyloxymethyl-1-(2-hydroxyethyl)pyrrolidine was obtained as a golden oil (0.48 g, yield: 85 %).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05854272 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-99aa1c44ff0d4f669c7243642ca5cc08 |
| Source note | uspto-grants-1998_12 |