Paclitaxel → Taxane

Participants

Reaction Steps

Batches of crude plant extracts from Taxus yunnanensis or from Taxus wallachiana containing approximately 15-40% cephalomannine, approximately 50-70% paclitaxel and approximately 20-35% other taxane/non-taxane components were obtained from the Peoples Republic of China. Chlorine gas was obtained from Matheson Ltd., and Silica gel used was ICN Silitech, 32-63 um, 60 Å, ICN Biomedicals, Inc., Aurora, Ohio. All solvents used were either HPLC or ACS grade and were obtained from Spectrum Chemical Mfg. Corp. Purified water used was deionized in-house.

Provenance & Evidence