p-Anisoyl chloride → HCID 54449783, compound

HRID 1459678Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]([CH3:12])[CH3:11])=[C:7]([C:13](=[O:29])[C:14]3[CH:19]=[C:18]([I:20])[C:17]([CH2:21][CH3:22])=[C:16]([I:23])[C:15]=3[O:24][CH2:25][C:26]([OH:28])=[O:27])[C:6]=2[CH:30]=1.[C:31](Cl)(=[O:40])[C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=1>>[CH:10]([C:8]1[O:9][C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:31](=[O:40])[C:32]3[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][CH:33]=3)=[CH:30][C:6]=2[C:7]=1[C:13](=[O:29])[C:14]1[CH:19]=[C:18]([I:20])[C:17]([CH2:21][CH3:22])=[C:16]([I:23])[C:15]=1[O:24][CH2:25][C:26]([OH:28])=[O:27])([CH3:12])[CH3:11]

Participants

Reactant 2

HCID 7477p-Anisoyl chloride

HCID 53797766HCID 53797766, compound

Product 1

HCID 54449783HCID 54449783, compoundYield 83%

Procedure

5-amino-2-isopropyl-3-(3 ,5-diiodo-4-ethyl carboxymethoxybenzoyl)-benzofuran (prepared as in Example 6(d), 150 mg, 0.25 mmol) was treated with anisoyl chloride as described in Example 3(a) to produce 160 mg (yield 83%) of 2-isopropyl-3-(3,5-diiodo-4-ethyl carboxymethoxybenzoyl)-5-(4-methoxybenzamido)benzofuran.

Sources & evidence

ORD record: ord-525db7a855ac48feb855ff2e5cf17372
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05854282

Reaction notes

Loading…