1,2-Cyclopentanedicarboxylic acid, (1R,2R)-rel- → cis-tetrahydro-1H-cyclopenta[c]furan-1,3(4H)-dione

Participants

Reaction Conditions

Reaction Steps

To the trans-cyclopentane-1,2-dicarboxylic acid (1.16 g, 7.33 mmol) at room temperature, was added Acetic anhydride (10 mL, ex). The reaction mixture was refluxed at about 165° C. for 14 hrs. Workup consisted of concentration in vacuo and co-evaporation with toluene three times. The crude product (1.0 g, ~100%, with a little impurity of Acetic anhydride) was given as a brown oily solid.

Provenance & Evidence