HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Aminobenzyl)-1,2,4-triazole → Des(dimethylamino)hydroxyrizatriptan
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Aminobenzyl)-1,2,4-triazole | HCID 821219 | — |
| Reactant | 1H-Indole-3-ethanol, 5-(4H-1,2,4-triazol-4-yl)- | HCID 10561309 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Des(dimethylamino)hydroxyrizatriptan | HCID 11791351 | — |
Reaction Steps
Prepared from 4-(1,2,4-triazol-1-ylmethyl)aniline (EP497512) as described for Intermediate 3, δ (250 MHz, D4 -MeOH) 2.96 (2H, t, J=7.2 Hz, CH2), 3.80 (2H, t, J=7.2 Hz, CH2), 5.46 (2H, s, CH2), 7.08 (1H, dd, J=1.7 and 8.6 Hz, Ar--H), 7.11 (1H, s, Ar--H), 7.33 (1H, d, J=8.6 Hz, Ar--H), 7.58-7.59 (1H, d, J=1.7 Hz, Ar--H), 7.97 (1H, s, Ar--H), 8.44 (1H, s, Ar--H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05854268 |
| Source dataset | uspto-grants-1998_12 |
| ORD ID | ord-f492789a35cf4d8d864906beaf17911c |
| Source note | uspto-grants-1998_12 |