m-Chloroperbenzoic acid → HCID 53770744, compound

Participants

Reaction Steps

Using a similar method to that described in Example 107, step 1, 1-(tert-butoxycarbonyl)-4-(4-fluorobenzylthio)piperidine (1.5065 g, 4.63 mmol) was reacted with 57-86% 3-chloroperoxybenzoic acid (1.0190 g) in dichloromethane (100ml) to give 1.5287 g (97%) of the title compound as a white solid. δH (250 MHz, CDCl3) 1.46 (9H, s), 1.64-1.82 (3H, m), 2.02 (1H, m), 2.63 (1H, m), 2.81 (2H, m), 3.88 (1H, d, J=13.2 Hz), 3.98 (1H, d, J=13.2 Hz), 4.21 (2H, m), 7.08 (2H, t, J=8.6 Hz), 7.29 (2H, m); m/e (ES+) 683 (2M+H)+, 342 (M+H)+.

Provenance & Evidence