HCID 53770744, compound → HCID 53690450, compound

HRID 1459730Notes

Reaction equation

HRID 1459730 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([S:14]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)=O>[F:23][C:20]1[CH:19]=[CH:18][C:17]([CH2:16][S:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:15])=[CH:22][CH:21]=1

Participants

3

Reactant 1

HCID 53770744HCID 53770744, compound

Product 1

HCID 53690450HCID 53690450, compoundYield 95.5%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Using a similar method to that described in Example 108, step 2, 1-(tert-butoxycarbonyl)-4-(4-fluorobenzylsulfinyl)piperidine (1.524 g, 4.46 mmol) was reacted with 90% formic acid (15ml) to give 1.0276 g (95%) of the title compound as a white solid. δH (250 MHz, CDCl3) 1.47 (2H, m), 1.82 (2H, m), 2.49 (2H, m), 2.69 (1H, tt, J=4.0 and 11.8 Hz), 3.03 (2H, m), 3.88 (1H, d, J=13.0 Hz), 4.11 (1H, d, J=13.0 Hz), 7.20 (2H, t, J=8.9 Hz), 7.37 (2H, m). m/e (ES+) 242 (M+H)+.

Sources & evidence

ORD record
ord-2eed0f77f07144a28aff129eeecc00e5
Source dataset
uspto-grants-1998_12
Patent number
US05854268

Reaction notes

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