5-Bromo-2,4-difluorobenzenesulfonamide → 5-[7-Cyclopropyl-5-(3,4-dichloro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-2,4-difluoro-benzenesulfonamide

HRID 145978Notes

Reaction equation

HRID 145978 reaction equation
[Br:23][c:24]1[c:25]([F:35])[cH:26][c:27]([F:34])[c:28]([S:30](=[O:31])(=[O:32])[NH2:33])[cH:29]1.[CH:1]1([c:4]2[cH:5][c:6](-[c:15]3[cH:16][c:17]([Cl:22])[c:18]([Cl:21])[cH:19][cH:20]3)[n:7][c:8]3[n:9]2[n:10][cH:11][c:12]3[C:13]#[CH:14])[CH2:2][CH2:3]1>>[CH:1]1([c:4]2[cH:5][c:6](-[c:15]3[cH:16][c:17]([Cl:22])[c:18]([Cl:21])[cH:19][cH:20]3)[n:7][c:8]3[n:9]2[n:10][cH:11][c:12]3[C:13]#[C:14][c:24]2[c:25]([F:35])[cH:26][c:27]([F:34])[c:28]([S:30](=[O:31])(=[O:32])[NH2:33])[cH:29]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 27732955-Bromo-2,4-difluorobenzenesulfonamideHCID 866080507-Cyclopropyl-5-(3,4-dichloro-phenyl)-3-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670009105-[7-Cyclopropyl-5-(3,4-dichloro-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-2,4-difluoro-benzenesulfonamide

Sources & evidence

ORD record
ord-a5393d8fabb24400b7c5ac92200c584c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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