Imidazole → HCID 19358829, compound

HRID 1460047Notes

Reaction equation

HRID 1460047 reaction equation
[CH2:1]([C:3]1[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[CH:14][N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=[C:5]([N:19]2[CH:23]=[CH:22][N:21]=[C:20]2CC)[N:4]=1)[CH3:2].N1C=CN=C1>CO>[CH2:1]([C:3]1[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[CH:14][N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=[C:5]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 795ImidazoleHCID 19358835HCID 19358835, compound

Product 1

HCID 19358829HCID 19358829, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 6 (5 g, 15 mmol) is heated with 50 g of imidazole at 200° C. under N2 for 16 h. The reaction mixture is cooled to ~100° C., and 150 mL methanol is added. The solids are filtered and washed with methanol to provide the title compound.

Workup

  1. temperatureThe reaction mixture is cooled to ~100° C.
  2. filtrationThe solids are filtered
  3. washwashed with methanol

Sources & evidence

ORD record
ord-ec43ca6e426c49a088966c0f2e46500c
Source dataset
uspto-grants-1998_12
Patent number
US05854419

Reaction notes

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