Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexene → 9-Ethyl-4-[(1-methylpiperidin-4-yl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexene | HCID 8079 | — |
| 반응물 | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| 반응물 | 2-Ethylimidazole | HCID 66130 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 1-Methyl-4-(methylamino)piperidine | HCID 566323 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 9-Ethyl-4-[(1-methylpiperidin-4-yl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 70270934 | — |
반응 단계
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with 1-methyl-4-(methylamino)piperidine followed by reaction with 2-ethylimidazole, reduction with palladium on carbon and cyclohexene in refluxing ethanol, and cyclization with carbonyidiimidazole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05854419 |
| 출처 데이터셋 | uspto-grants-1998_12 |
| ORD ID | ord-41d41a53e74f40a5bddc10040f9340f4 |
| 출처 메모 | uspto-grants-1998_12 |