反应详情

In 10 ml of ethanol was dissolved 0.86 g (10 mmol.) of 35% formalin. To the solution placed in an ice bath was further added a solution of 1.94 g (10 mmol., purity 90.7%) of methyl 1-piperazinecarbodithioate in 4 ml of ethanol. The resulting mixture was then stirred for 30 min. at room temperature. To the mixture placed in an ice bath was dropwise added a solution of 2.12 g (10 mmol.) of propyl gallate in 4 ml of ethanol. The mixture was stirred overnight at room temperature and subsequently refluxed under heating for 4 hours. The mixture was cooled to room temperature. Precipitated crystals were collected by filtration and washed with ethanol to give 1.843 g of the desired compound as a grayish powder, m.p. 142°-144° C. (decomp.), yield 31.3%.

1. customTo the solution placed in an ice bath
2. customTo the mixture placed in an ice bath
3. stirringThe mixture was stirred overnight at room temperature
4. temperaturesubsequently refluxed
5. temperatureunder heating for 4 hours
6. temperatureThe mixture was cooled to room temperature
7. customPrecipitated crystals
8. filtrationwere collected by filtration
9. washwashed with ethanol