1-Bromo-3-chloropropane → HCID 15020374, compound

Participants

Reaction Steps

A mixture of 1 mole of 4-hydroxy-3-methoxy-α-oxobenzeneacetic acid ethyl ester, 2 mole of 1-bromo-3-chloropropane and 3 mole of anhydrous potassium carbonate in 3 liters of acetone is heated at reflux for 20 hr. The mixture is cooled, filtered and the filtrate concentrated to give a solid residue. The solid is triturated with petroleum ether (30°-60° C.), collected by filtration and dried to give the title compound.

Provenance & Evidence