Potassium Iodide → HCID 19983119, compound

Participants

Reaction Steps

A mixture of α,α-bis(4-fluorophenyl)-4-piperidineacetamide (6.94 g, 0.021 mole), 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone (5.09 g, 0.021 mole), and potassium carbonate (5.53 g, 0.04 mole) was heated overnight at reflux in 350 ml of 1-butanol containing potassium iodide (0.2 g). The mixture was concentrated to dryness. The residue obtained was partitioned between chloroform and water. The chloroform layer was dried (sodium sulfate) and filtered. The solvent was removed to give a yellowish-brown residue. This material was converted to the fumarate, and the salt was recrystallized from methanol-diethyl ether. A white solid was obtained and dried in vacuo overnight at 80° C. This method provided 8.47 g (66.8%) of white, crystalline product, mp 258°-260° C. (dec).

Provenance & Evidence