Sodium borohydride → HCID 19983117, compound

HRID 1460262Notes

Reaction equation

[C:1]([C:4]1[CH:37]=[CH:36][C:7]([O:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[C:19]([NH2:21])=[O:20])[CH2:14][CH2:13]2)=[C:6]([O:38][CH3:39])[CH:5]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>>[F:28][C:25]1[CH:24]=[CH:23][C:22]([C:18]([C:29]2[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=2)([CH:15]2[CH2:14][CH2:13][N:12]([CH2:11][CH2:10][CH2:9][O:8][C:7]3[CH:36]=[CH:37][C:4]([CH:1]([OH:3])[CH3:2])=[CH:5][C:6]=3[O:38][CH3:39])[CH2:17][CH2:16]2)[C:19]([NH2:21])=[O:20])=[CH:27][CH:26]=1

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 15020380HCID 15020380, compound

Product 1

HCID 19983117HCID 19983117, compound

Procedure

Using the procedure of Example 20, 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-4-piperidineacetamide is reduced with sodium borohydride to give the title compound.

Sources & evidence

ORD record: ord-322068930dae4fe49dfaf3bef3af5e99
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05070087

Reaction notes

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