Sodium borohydride → HCID 19983085, compound

HRID 1460263Notes

Reaction equation

[NH2:1][C:2]([C:31]1[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=1)([C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)[CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19](=[O:21])[CH3:20])=[CH:15][C:14]=2[O:22][CH3:23])[CH2:5][CH2:4]1.[BH4-].[Na+]>>[NH2:1][C:2]([C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)([C:31]1[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=1)[CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH:19]([CH3:20])[OH:21])=[CH:15][C:14]=2[O:22][CH3:23])[CH2:5][CH2:4]1

Participants

Reactant 2

HCID 4311764Sodium borohydride

HCID 15093869HCID 15093869, compound

Product 1

HCID 19983085HCID 19983085, compound

Procedure

Using the procedure of Example 20, 1-[4-[3-[4-[aminobis(4-fluorophenyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]-1-ethanone is reduced with sodium borohydride to give the title compound.

Sources & evidence

ORD record: ord-b7face2be2df4df2989d096450844665
Source dataset: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05070087

Reaction notes

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