反应详情

To 4-[2-(3,4-dichloro-phenoxy)-acetylamino]-thiophene-3-carboxylic acid methyl ester (80 mg, 0.222 mmol) in suspension in ethanol was added an aqueous solution of sodium hydroxide (1N, 0.333 mL, 0.333 mmol) and the reaction mixture was stirred at room temperature for 48 hours. After such time the reaction mixture was filtered and the filtrate was neutralized by addition of an aqueous solution of hydrochloric acid (1N, 0.335 mL). The precipitate was then isolated by filtration, washed with water and dried in vacuo to yield the title compound as a white solid (62.1 mg, 80%).

1. filtrationAfter such time the reaction mixture was filtered
2. additionthe filtrate was neutralized by addition of an aqueous solution of hydrochloric acid (1N, 0.335 mL)
3. customThe precipitate was then isolated by filtration
4. washwashed with water
5. customdried in vacuo