反应详情

温度

100 °C

A mixture of 3-amino-4-(4-cyanophenyl)amino-2,6-dimethylpyridine (4.20 g, 17.6 mmol), acetic anhydride (12.6 ml) and acetic acid (12.6 ml) was stirred at 100° C. for 16 hours. The excess of reagents was removed under reduced pressure, and the residual gum was dissolved in water and the solution was rendered basic by the addition of concentrated aqueous ammonia. The white solid which precipitated was filtered off and dried in vacuo to give the title compound (4.06 g, 88%), mp 260°-262° C.

1. customThe excess of reagents was removed under reduced pressure
2. dissolutionthe residual gum was dissolved in water
3. additionthe solution was rendered basic by the addition of concentrated aqueous ammonia
4. customThe white solid which precipitated
5. filtrationwas filtered off
6. customdried in vacuo