Methane → HCID 19981615, compound

Participants

Reaction Steps

0.77g of 2-amino-3-chlorophenyl allyl ether in 12ml of dry pyridine were treated with 1.03g of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine-2-sulphonyl chloride and stirred at ambient temperature overnight. The pyridine was removed by evaporation with final traces eliminated by means of a vacuum pump. An oily brown product was obtained which was stirred with 30ml of 1M sodium hydroxide for 20 minutes to give a brown solution. Charcoal (20-30mg) was added and the mixture stirred for 10 minutes and then filtered through Celite ("Celite" is a trade mark). The filtrate was cooled, acidified with 10% hydrochloric acid to pH 1-2 to produce a solid which was then filtered off, washed with water and dried in vacuo to give 1.2g (a yield of 73%) of 5,7-dimethyl-2-(N-[2-allyloxy-6-chlorophenyl]-sulphamoyl)-1,2,4-triazolo[1,5-a]pyrimidine (Compound No. 1).

Provenance & Evidence