Methyl Ethyl Ketone → Ethyl 2-acetyl-5-{4-[(4-fluorophenyl)phenylmethylene]piperidino}pentanoate

HRID 1460450노트

반응식

HRID 1460450 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.C([CH:24]([CH2:31][CH2:32]Cl)[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])(=O)C.C(=O)([O-])[O-].[Na+].[Na+].[CH3:40][C:41](=[O:44])CC>>[C:41]([CH:25]([CH2:24][CH2:31][CH2:32][N:12]1[CH2:11][CH2:10][C:9](=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:14][CH2:13]1)[C:26]([O:28][CH2:29][CH3:30])=[O:27])(=[O:44])[CH3:40]

참가 물질

5

반응물 4

HCID 6569Methyl Ethyl KetoneHCID 10340Sodium CarbonateHCID 150203584-[(4-Fluorophenyl)(phenyl)methylidene]piperidineHCID 19915760HCID 19915760, 화합물

생성물 1

HCID 54340777Ethyl 2-acetyl-5-{4-[(4-fluorophenyl)phenylmethylene]piperidino}pentanoate

실험 절차

0.019 mol of 4-[(4-fluorophenyl)phenylmethylene]-piperidine, 0.019 mol of ethyl 3-acetyl-5-chloropentanoate, blocked in cyclic form (Chem. Ber. (1967), 100, p. 1675-1679), and 2.03 g of sodium carbonate in 80 ml of 2-butanone are brought to reflux. After evaporation of the solvent, the residue is taken up in water and extracted with dichloromethane. Deprotection is then performed according to the method described in Chem. Ber. (1967), 100, p. 1675-1679.

후처리

  1. temperatureto reflux
  2. customAfter evaporation of the solvent
  3. extractionextracted with dichloromethane

출처 및 근거

ORD 기록
ord-454019243bb04d40a82da9633a6fe88d
출처 데이터셋
uspto-grants-1991_12
특허 번호
US05071847

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