Formic Acid → HCID 14624182, compound

Participants

Reaction Steps

8 g (18.5 mmol) of base of the compound P are dissolved with cooling in 2.1 ml (56 mmol) of formic acid, stirred for 10 min, then treated at 25° C. in 1.6 ml of 40% strength formaldehyde (23 mmol) and then taken for 10 min to an oil bath preheated to 80° C. The mixture is cooled, taken up in methylene chloride and alkalinized with caustic soda solution. The phases are separated, the aqueous phase is re-extracted with the same solvent and the organic phases are combined, washed with saline solution and then dried and evaporated. The residue is converted to hydrochloride as in Example 2, to give the compound B, possessing the same characteristics as those described in Example 2, in a 90% yield.

Provenance & Evidence