4-(2-Bromoethyl)phenol → HCID 22841643, compound

HRID 1460481Notes

Reaction equation

HRID 1460481 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[CH2:11][S:10](=[O:19])(=[O:18])[C:9]2[CH:20]=[CH:21][CH:22]=[CH:23][C:8]1=2.[OH:24][C:25]1[CH:33]=[CH:32][C:28]([CH2:29][CH2:30]Br)=[CH:27][CH:26]=1>>[OH:24][C:25]1[CH:33]=[CH:32][C:28]([CH2:29][CH2:30][N:1]2[CH2:5][CH2:4][CH2:3][C@H:2]2[CH2:6][N:7]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[CH2:11][S:10](=[O:19])(=[O:18])[C:9]3[CH:20]=[CH:21][CH:22]=[CH:23][C:8]2=3)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 842214-(2-Bromoethyl)phenolHCID 22841646HCID 22841646, compound

Product 1

HCID 22841643HCID 22841643, compound

Procedure

This was obtained by reacting (S)-5,11-dihydro-5-(2-pyrrolidinylmethyl)dibenzo[b,e][1,4]thiazepine-10,10-dioxide (see Preparation 20) and 4-hydroxyphenethyl bromide by a similar method to that described in Example 28. The title compound was obtained as a colourless oil, (60 mg, 29%).

Workup

  1. customThis was obtained

Sources & evidence

ORD record
ord-3366cfdc955f4b739d981eefa6395c5f
Source dataset
uspto-grants-1991_12
Patent number
US05071844

Reaction notes

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