Thionyl Chloride → HCID 67836103, compound

Participants

Reaction Steps

Thionyl chloride (2ml) was added slowly to a solution of (S)-2-(2-hydroxyethyl)-1-(4-methoxyphenethyl)pyrrolidine (see Preparation 9) (3.0 g) in dichloromethane (30 ml). The mixture was heated under reflux for 2 hours and evaporated under reduced pressure to give the title compound as a brown oil, (4.15 g), which was characterised by NMR and used directly in Example 5 without further purification.

Provenance & Evidence