Dicyclohexylcarbodiimide → HCID 67834914, compound

Participants

Reaction Steps

A solution of 1,3-dicyclohexylcarbodiimide (DCC) (705 g) in dichloromethane (1400 ml) was added over 30 minutes to a stirred solution of 2-(2-bromophenylmethylthio)aniline (see Bull. Chem. Soc. Japan, 48, 2323 (1975)) (957 g) and (S)-1-(4-methoxyphenylacetyl)proline (see Preparation 24) (900 g) in dichloromethane (5.5 L). The mixture was stirred at 25°-35° C. for one hour and filtered. The filtrate was evaporated under reduced pressure to give the desired product as a brown gum which was used directly in Preparation 22.

Provenance & Evidence