Ethane, 1-chloro-2-ethoxy- → 3-(2-ethoxyethyl)-2-(1-methylpiperidin-4-yl)-3H-imidazo [4,5-b] pyridine
반응식
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:16][C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)[CH2:4][CH2:3]1.[CH2:17]([O:19][CH2:20][CH2:21]Cl)[CH3:18]>>[CH2:17]([O:19][CH2:20][CH2:21][N:16]1[C:11]2=[N:12][CH:13]=[CH:14][CH:15]=[C:10]2[N:9]=[C:8]1[CH:5]1[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]1)[CH3:18]참가 물질
3
실험 절차
Operation is carried out similarly to the above description with the difference that 2-(1-methylpiperidin-4-yl)-3H-imidazo [4,5-b] pyridine is reacted with 2-ethoxyethyl chloride to obtain 3-(2-ethoxyethyl)-2-(1-methylpiperidin-4-yl)-3H-imidazo [4,5-b] pyridine which is isolated as hemitrifumarate melting at 157°-158° C. (ethyl alcohol).
출처 및 근거
- ORD 기록
- ord-99ecf9a46e52449993c197393d009dd5
- 출처 데이터셋
- uspto-grants-1991_12
- 특허 번호
- US05071855
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