Furan, 2-(bromomethyl)tetrahydro- → HCID 19982130, compound

HRID 1460500Notes

Reaction equation

HRID 1460500 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:16][C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[N:9]=2)[CH2:4][CH2:3]1.[CH2:17](Br)[CH:18]1[O:22][CH2:21][CH2:20][CH2:19]1>>[CH2:17]([N:16]1[C:11]2=[N:12][CH:13]=[CH:14][CH:15]=[C:10]2[N:9]=[C:8]1[CH:5]1[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]1)[CH:18]1[O:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 14501Furan, 2-(bromomethyl)tetrahydro-HCID 178480226HCID 178480226, compound

Product 1

HCID 19982130HCID 19982130, compound

Procedure

Operation is carried out similarly to the above description with the difference that 2-(1-methylpiperidin-4-yl)-3H-imidazo [4,5-b] pyridine is reacted with tetrahydrofurfurylbromide to obtain 3-tetrahydrofurfuryl-2-(1-methylpiperidin-4-yl)-3H-imidazo [4,5-b] pyridine which is isolated as difumarate melting at 154°-156° C. (ethyl alcohol).

Sources & evidence

ORD record
ord-939ac97497e941aeb6499fabb3824785
Source dataset
uspto-grants-1991_12
Patent number
US05071855

Reaction notes

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