Triethylamine → HCID 19982155, compound

Participants

Reaction Steps

To a solution of 400 mg 6-fluoro-3-(4-[hydroxymethyl]-piperidinomethyl)-3,4-dihydro-2H-1-benzothiopyran and 200 mg triethylamine in 10 ml methylene chloride is added 221 mg p-fluorobenzoyl chloride. After 30 minutes at room temperature the reaction mixture is washed with 1 N sodium hydroxide, dried over magnesium sulfate and the solvent is removed in vacuo. The residue is triturated with ether/hexane to afford the title compound, m.p. 113°-114° C.

Provenance & Evidence