2-Nitrophenyl isothiocyanate → Ethyl 3-[[[(2-nitrophenyl)amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate

Participants

Reaction Steps

A mixture of 15.8 parts of ethyl 3-amino-1-pyrrolidinecarboxylate, 18 parts of 1-isothiocyanato-2-nitrobenzene and 180 parts of tetrahydrofuran was stirred for 1 hour at room temperature. The reaction mixture was evaporated, yielding 34 parts (100%) of ethyl 3[[[(2-nitrophenyl)amino]thioxomethyl]amino]-1-pyrrolidinecarboxylate as a residue (int. 22).

Provenance & Evidence