Water → HCID 19982191, compound

Participants

Reaction Steps

A mixture of 2-([1,1'-bipheny]-4-yl)-2-(bromomethyl)-1,3-dioxolane (16 g.), 3-hydroxypyridine (5.7 g.) and potassium carbonate (9 g.) were refluxed with stirring in N,N-dimethylacetamide (75 ml.) for 18 hours. After refluxing, the mixture was allowed to cool and was thereafter poured into water (150 ml.). The resultant aqueous solution was extracted twice with ether. The combined ether fractions were washed once with 5% aqueous sodium hydroxide and 4 times with water. The washed ether fractions were then dried, filtered and the solvent evaporated to yield 3-[[2-([1,1'-biphenyl]-4-yl)-1,3-dioxolan-2-yl]methoxy]pyridine as an oil.

Provenance & Evidence