HCID 15029755, compound → HCID 14231165, compound

HRID 1460558Notes

Reaction equation

HRID 1460558 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)(O)[CH:10]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1>S(Cl)(Cl)=O>[CH3:32][O:31][C:28]1[CH:29]=[CH:30][C:25]([C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[C:10]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[C:11]2[CH:12]=[CH:13][C:14]([C:17]#[N:18])=[CH:15][CH:16]=2)=[CH:26][CH:27]=1

Participants

3

Reactant 1

HCID 15029755HCID 15029755, compound

Product 1

HCID 14231165HCID 14231165, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

2,2-Bis-(4-methoxyphenyl)-2-hydroxy-1-(1-imidazolyl)-1-(4-cyanophenyl)-ethane (10.2 g) is dissolved in thionyl chloride (25 mL) and the solution is stirred at room temperature for 36 hours. The solvent is evaporated and the residue is chromatographed on silica gel (250 g). Elution with ethyl acetate affords the crystalline 2,2-bis-(4-methoxyphenyl)-1-(1-imidazolyl)-1-(4-cyanophenyl)-ethylene. The compound has m.p. 174°-176° after recrystallization from isopropanol.

Workup

  1. customThe solvent is evaporated
  2. customthe residue is chromatographed on silica gel (250 g)
  3. washElution with ethyl acetate

Sources & evidence

ORD record
ord-74ef1516da124b6bbf2e79f4fde888ad
Source dataset
uspto-grants-1991_12
Patent number
US05071861

Reaction notes

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