Nitric Acid → HCID 15675931, compound

Participants

Reaction Conditions

Reaction Steps

5-Fluoro-4-methyl-2-benzoxazolone (Preparation A, 2.01 g, 12 mmoles) was treated with concentrated nitric acid (24 ml) at room temperature under stirring. The mixture was heated to 50° C. and stirring continued for 20 minutes. Ice and water were added to the mixture and the resulting solids were collected, and washed with water and then with ethanol. The crude product was dried under reduced pressure and recrystallized from ethanol to give 1.84 g (72%) of the title compound: m.p. 194°-196° C.

Provenance & Evidence