HCID 19106962, compound → HCID 15657652, compound

HRID 1460578Notes

Reaction equation

HRID 1460578 reaction equation
[CH:1]1[C:10]2[C:9]3([C:15]([OH:17])=[O:16])[CH2:11][CH:12]=[CH:13][CH2:14][CH:8]3[CH2:7][S:6][C:5]=2[CH:4]=[CH:3][CH:2]=1>CO.[Pd]>[CH:1]1[C:10]2[C:9]3([C:15]([OH:17])=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH:8]3[CH2:7][S:6][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 19106962HCID 19106962, compound

Product 1

HCID 15657652HCID 15657652, compoundYield 79.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of the product from Example 19 (4.35 g) in methanol (100 ml) was added palladium on charcoal 5%, 0.5 g). The solution was hydrogenated (50 psi) and the suspension filtered through Hyflow. Evaporation of solvent gave the title compound as a colorless crystalline solid (3.5 g). Treatment of the catalyst residue with hot methanol afforded the remaining of the title compound (0.8 g), mp 200°-203° C.

Workup

  1. filtrationthe suspension filtered through Hyflow
  2. customEvaporation of solvent

Sources & evidence

ORD record
ord-259d54db598d4bacbebaf7ed03cf7f03
Source dataset
uspto-grants-1991_12
Patent number
US05071853

Reaction notes

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