Boron tribromide → HCID 15657723, compound

Participants

Reaction Steps

To a solution of the product from Example 128 (0.20 g) in CH2Cl2 (10 ml) was added BBr3 (2 ml of a 1.0M solution in CH2Cl2. The reaction was stirred at room temperature for 18 hours and quenched by the addition of water. Additional CH2Cl2 (10 ml) and 1N HCl (20 ml) was added. The aqueous phase was separated, and made basic (pH=10) by the addition of NaHCO3. The aqueous phase was extracted with EtOAc (5×10 ml). The combined organic phases were dried over MgSO4, filtered and concentrated. The residue was dissolved in 0.5N HCl and freeze dried to give the title compound as a white solid (90 mg, 41%), mp 156°-161° C.

Provenance & Evidence